How SeraSeal works
SeraSeal supports the patient’s own blood coagulation process, and acts as a catalyst in the clot formation process. The active ingredients responsible are agar and coagulation factors IIa, VIIa, IXa, Xa.
is a polysaccharide/carbohydrate and a linear complex sugar made from beta-galactopyranose linked to 3,6-anhydro-L-galactopyranose. Agar is used in gelatin, emulsifiers, thickeners and gelling agents. When applied to bleeding wounds, agar creates cross-links between fibrinogen/fibrin monomers and tissue proteins via the ions in blood platelet phospholipids and the cations in amino groups, thus forming an α-1.6-linked galactophospho- and an α-1,6-galactoamine bond, and creating a gelatin-like barrier over the wound. This barrier reduces the amount of blood escaping through the wound opening, and enables the more rapid formation of a fibrin clot by the patient’s cascade system.
\\\ COAGULATION FACTORS IIA, VIIA, IXA, XA
Coagulation factors IIa, VIIa, IXa, and Xa function in an ancillary way by helping the agar to cross-link with the blood platelets and fibrinogen, thus strengthening the gelatin barrier.
Tissue thromboplastin from platelets, which has been activated by damaged cells, assists in forming a clot. Covalent lysine to glutamine linkages between gamma chains of adjacent fibrin molecules, and between adjacent alpha chains, ensure clot stabilisation.