Icon Wirkung

How SeraSeal works

SeraSeal supports the patient’s own blood coagulation process, and acts as a catalyst in the clot formation process. The active ingredients responsible are agar and coagulation factors IIa, VIIa, IXa, Xa.


\\\ Agar

is a polysaccharide/carbohydrate and a linear complex sugar made from beta-galactopyranose linked to 3,6-anhydro-L-galactopyranose. Agar is used in gelatin, emulsifiers, thickeners and gelling agents. When applied to bleeding wounds, agar creates cross-links between fibrinogen/fibrin monomers and tissue proteins via the ions in blood platelet phospholipids and the cations in amino groups, thus forming an α-1.6-linked galactophospho- and an α-1,6-galactoamine bond, and creating a gelatin-like barrier over the wound. This barrier reduces the amount of blood escaping through the wound opening, and enables the more rapid formation of a fibrin clot by the patient’s cascade system.


Coagulation factors IIa, VIIa, IXa, and Xa function in an ancillary way by helping the agar to cross-link with the blood platelets and fibrinogen, thus strengthening the gelatin barrier.

Tissue thromboplastin from platelets, which has been activated by damaged cells, assists in forming a clot. Covalent lysine to glutamine linkages between gamma chains of adjacent fibrin molecules, and between adjacent alpha chains, ensure clot stabilisation.

The clotting factors in SeraSeal™ support the physiological clotting cascade, and act as a catalyst in forming Fibrin.